Synthesis of nitrogen heterocycles via α-aminoalkyl radicals generated from α-silyl secondary amines under visible light irradiation.
نویسندگان
چکیده
We have succeeded in the visible light-mediated synthetic use of α-aminoalkyl radicals derived from α-silyl secondary amines toward addition to α,β-unsaturated carbonyl compounds. The resulting γ-aminocarbonyl compounds are converted into γ-lactams and pyrroles in a one-pot process.
منابع مشابه
Synthesis of nitrogen heterocycles via a-aminoalkyl radicals generated from a-silyl secondary amines under visible light irradiation†
Five-membered nitrogen heterocycles such as g-lactams and pyrroles are found in various natural products and pharmaceuticals. Construction of these skeletons in a simple and efficient manner is one of the most important topics in synthetic organic chemistry. In this context, the development of a novel synthetic approach for g-aminocarbonyl compounds composed of a secondary or primary amine moie...
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ورودعنوان ژورنال:
- Chemical communications
دوره 50 64 شماره
صفحات -
تاریخ انتشار 2014